Detection of Circulating Tumor Cells. (15th July 2014)

• Record Type: Journal Article
• Authors: de Wit, Sanne; van Dalum, Guus; Terstappen, Leon W. M. M.
• Other Names: Yoshida Hiroki Academic Editor.
• Is Part Of: Scientifica. Volume 2014(2014)
• Publication Date: 2014-07-15
• Subjects: Life sciences -- Periodicals; Biology -- Periodicals; Medicine -- Periodicals; Biological Science Disciplines; Medicine; Biology; Life sciences; Medicine; Periodicals; Electronic journals; Periodicals; 500
• DOI: 10.1155/2014/819362
• Languages: English
• ISSNs: 2090-908X

Abstract

Abstract : The increasing number of treatment options for patients with metastatic carcinomas has created an accompanying need for methods to determine if the tumor will be responsive to the intended therapy and to monitor its effectiveness. Ideally, these methods would be noninvasive and provide quantitative real-time analysis of tumor activity in a variety of carcinomas. Assessment of circulating tumor cells shed into the blood during metastasis may satisfy this need. Here we review the CellSearch technology used for the detection of circulating tumor cells and discuss potential future directions for improvements.