Antifungal and Antibacterial Metabolites from a French Poplar Type Propolis. (22nd March 2015)

• Record Type: Journal Article
• Authors: Boisard, Séverine; Le Ray, Anne-Marie; Landreau, Anne; Kempf, Marie; Cassisa, Viviane; Flurin, Catherine; Richomme, Pascal
• Other Names: Seidel Veronique Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2015(2015)
• Publication Date: 2015-03-22
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2015/319240
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : During this study, the in vitro antifungal and antibacterial activities of different extracts (aqueous and organic) obtained from a French propolis batch were evaluated. Antifungal activity was evaluated by broth microdilution on three pathogenic strains: Candida albicans, C. glabrata, and Aspergillus fumigatus . Antibacterial activity was assayed using agar dilution method on 36 Gram-negative and Gram-positive strains including Staphylococcus aureus . Organic extracts showed a significant antifungal activity against C. albicans and C. glabrata (MIC80 between 16 and 31 µ g/mL) but only a weak activity towards A. fumigatus (MIC80 = 250 µ g/mL). DCM based extracts exhibited a selective Gram-positive antibacterial activity, especially against S. aureus (SA) and several of its methicillin-resistant (MRSA) and methicillin-susceptible (MSSA) strains (MIC100 30–97 µ g/mL). A new and active derivative of catechin was also identified whereas a synergistic antimicrobial effect was noticed during this study.