Nasal Nitric Oxide Levels in HIV Infection: A Cross-Sectional Study. (9th January 2018)

• Record Type: Journal Article
• Authors: Costiniuk, Cecilia T.; Mehraj, Vikram; Routy, Jean-Pierre; de Castro, Christina; Wasef, Natale; Jenabian, Mohammad-Ali; Salahuddin, Syim; Lebouché, Bertrand; Cox, Joseph; Szabo, Jason; Klein, Marina; Lands, Larry; Shapiro, Adam J.
• Other Names: Nicholas Patrice K. Academic Editor.
• Is Part Of: AIDS research and treatment. Volume 2018(2018)
• Publication Date: 2018-01-09
• Subjects: AIDS (Disease) -- Periodicals; AIDS (Disease) -- Research -- Periodicals; AIDS (Disease) -- Treatment -- Periodicals; AIDS (Disease) -- Patients -- Care -- Periodicals; AIDS (Disease) -- Patients -- Services for -- Periodicals; 616.979205
• DOI: 10.1155/2018/7645125
• Languages: English
• ISSNs: 2090-1240

Abstract

Abstract : Introduction . Low levels of nasal NO have been associated with increased propensity to rhinosinusitis and respiratory tract infections. Our objective was to describe nasal NO levels in HIV-infected individuals versus healthy controls and determine possible risk factors for reduced nasal NO levels. Materials and Methods . HIV-infected individuals and healthy controls were recruited. Participants underwent nasal NO testing by standardized methods using a CLD88 chemiluminescence analyzer and completed the Sinonasal Outcome Test-20 (SNOT-20) on symptoms of rhinosinusitis. Results . Participants included 41 HIV-infected individuals with suppressed VL on antiretroviral therapy (ART group), 5 HIV-infected individuals with detectable VL off ART (viremic group), and 12 healthy controls (HC group). Mean nasal NO level was 253 (±77) nL/min in the ART group, 213 (±48) nL/min in the viremic group, and 289 (±68) nL/min in the HC group (p = 0.133 ; ANOVA). There was no correlation between nasal NO level and VL in viremic individuals (r = - 0.200 ;p = 0.747 ). Differences were observed in mean total points on the SNOT-20 which were 19 (±16)/100, 18 (±26)/100, and 4 (±4)/100 in the ART, viremic, and HC groups, respectively (p = 0.013 ; ANOVA). Conclusion . Healthy individuals, HIV patients on ART, and viremic individuals off ART display similar nasal NO levels. However, rhinosinusitis symptoms remain prominent despite ART-treatment.