Analgesic effect of Allium ampeloprasum: Evidence for the involvement of beta-adrenergic system. (June 2019)

• Record Type: Journal Article
• Authors: Abbas, Manal A.
• Is Part Of: Journal of functional foods. Volume 57(2019)
• Page Start: 1
• Page End: 6
• Publication Date: 2019-06
• Subjects: Allium ampeloprasum -- Analgesic -- Antinociceptive -- Beta-adrenergic receptor -- Antidepressant -- Anxiolytic; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2019.03.046
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: A. ampeloprasum had antinociceptive action in chemical and thermal pain models. β-adrenergic receptor is involved in A. ampeloprasum analgesic action. A. ampeloprasum had no antidepressant or anxiolytic effects. Phytol acetate, linoleic acid and tricosane were the major constituents in the extract. Abstract: Allium ampeloprasum (leek) is a bulbous perennial edible vegetable closely related to garlic ( A. sativum L.). In this study, the antinociceptive, antidepressant and anxiolytic effects of A. ampeloprasum were studied. A. ampeloprasum inhibited abdominal cramps in writhing test and increased latency time in hot-plate and tail-flick tests. In formalin test, A. ampeloprasum inhibited paw licking in both early and late phases. Propranolol, but not naloxone or yohimbine, reversed this effect. A. ampeloprasum decreased the number of lines crossed in open field test but has no effect on the time spent in open arm in elevated plus maze or the immobility time in forced swimming test. GC–MS analysis resulted in the identification of 18 compounds with phytol acetate, linoleic acid and tricosane as major constituents. In conclusion, the analgesic action of A. ampeloprasum was mediated by interaction with β-adrenergic receptor. No antidepressant or anxiolytic effects were exerted by A. ampeloprasum .