Acmella oleracea and Achyrocline satureioides as Sources of Natural Products in Topical Wound Care. (29th September 2016)

• Record Type: Journal Article
• Authors: Yamane, Lais Thiemi; de Paula, Eneida; Jorge, Michelle Pedroza; de Freitas-Blanco, Verônica Santana; Junior, Ílio Montanari; Figueira, Glyn Mara; Anholeto, Luís Adriano; de Oliveira, Patricia Rosa; Rodrigues, Rodney Alexandre Ferreira
• Other Names: Dudai Nativ Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2016(2016)
• Publication Date: 2016-09-29
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2016/3606820
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : The Brazilian forests have one of the world's biggest biodiversities. Achyrocline satureioides (macela) and Acmella oleracea (jambu) are native species from Brazil with a huge therapeutic potential, with proved anti-inflammatory and anesthetic action, respectively. The jambu's crude extract after depigmentation with activated charcoal and macela's essential oil were incorporated in a film made with hydroxyethyl cellulose. Those films were evaluated by mechanical test using a texturometer and anti-inflammatory and anesthetic activities by in vivo tests: wound healing and antinociceptive. The film containing the highest concentration of depigmented jambu's extract and macela's essential oil obtained an anesthesia time of 83.6 (±28.5) min longer when compared with the positive control EMLA®; the same occurred with the wound healing test; the film containing the highest concentration had a higher wound contraction (62.0 % ± 12.1 ) compared to the positive control allantoin and the histopathological analysis demonstrated that it increases collagen synthesis and epidermal thickening. The results demonstrate that the films have a potential use in skin wounds, pressure sore, and infected surgical wounds treatment.