Traditional Chinese Herbal Patch for Short-Term Management of Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Trial. (13th February 2012)

• Record Type: Journal Article
• Authors: Wang, Xuezong; Cao, Yuelong; Pang, Jian; Du, Jiong; Guo, Chaoqing; Liu, Ting; Wei, Songpu; Zheng, Yuxin; Chen, Rongming; Zhan, Hongsheng
• Other Names: Litscher Gerhard Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2012(2012)
• Publication Date: 2012-02-13
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2012/171706
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Objective . To assess the short-term efficacy and safety of two kinds of Traditional Chinese herbal patches, Fufang Nanxing Zhitong Gao (FNZG) and Shangshi Jietong Gao (SJG), for painful knee osteoarthritis (OA). Methods . Patients were randomly enrolled in a double-blind, placebo-controlled study to receive FNZG (n = 60 ), SJG (n = 60 ), or placebo patch (n = 3 0 ) for 7 days. Outcome measures included visual analogue scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Traditional Chinese Medicine Syndrome Questionnaire (TCMSQ) subscale . Results . Although there was no significant difference among, three groups in short-term pain management, patients receiving FNZG got significant improvement in symptom of fear of coldness as compared with placebo patch (P = 0.029 ). The most common local adverse events of rash, itching, erythema, and slightly damaged skin were observed in 7% of participants. Conclusions . FNZG may be a useful treatment for symptom of knee OA and merits long-term study in broader populations.