Shrinkage of Prostate and Improved Quality of Life: Management of BPH Patients with Croton membranaceus Ethanolic Root Extract. (2nd April 2015)

• Record Type: Journal Article
• Authors: Asare, George Awuku; Afriyie, Daniel; Ngala, Robert A.; Appiah, Alfred A.; Anang, Yvonne; Musah, Iddi; Adjei, Samuel; Bamfo-Quaicoe, Kwabena; Sule, Derick; Gyan, Ben A.; Arhin, Peter; Edoh, Dominic A.
• Other Names: Oberbaum Menachem Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2015(2015)
• Publication Date: 2015-04-02
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2015/365205
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Benign prostatic hyperplasia (BPH) is an enlargement of the prostate. The study aimed at validating the use of freeze-dried Croton membranaceus ethanolic root extract for BPH management. Thirty-three patients were observed before and after 3-month administration of 20 mg t.i.d orally. The International Prostate Symptom Score (IPSS), and the International Index of Erectile Function (IIEF) questionnaires were used. Total/free PSA (tPSA, fPSA), renal, liver function, lipid tests, and ultrasonographic imaging were performed. Thirty (30) patients (66 ± 11 years) completed the study. IPSS results showed 37% had severe, 40% moderate, and 23% mild symptoms before; 57% and 43% had moderate and mild symptoms, respectively, after treatment. IIED of patients' results showed 30% with severe, 40% moderate, 24% mild-moderate, 3% mild, and 3% no erectile dysfunction before treatment and 20% severe, 43% moderate, and 37% mild-moderate dysfunction, after treatment. Quality of life (QoL) improved( P = 0.001 ) . Significant but non-pathological increases in total and indirect bilirubin as well as apolipoprotein A occurred. Mean tPSA reduced from 27.9 ± 19.0 to 16.2 ± 11.8 ng/mL( P = 0.002 ) ; fPSA from 6.1 ± 4.8 to 3.9 ± 2.9 ng/mL( P = 0.045 ) ; and prostate volume from 101.8 ± 41.3 to 54.5 ± 24.8 cm 3 ( P = 0.023 ) . C. membranaceus shrinks the prostate and improves QoL.