Evaluation of α-Glucosidase Inhibitory Effect of 50% Ethanolic Standardized Extract of Orthosiphon stamineus Benth in Normal and Streptozotocin-Induced Diabetic Rats. (16th November 2015)

• Record Type: Journal Article
• Authors: Mohamed, Elsnoussi Ali; Ahmad, Mariam; Ang, Lee Fung; Asmawi, Mohd. Zaini; Yam, Mun Fei
• Other Names: Hennebelle Thierry Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2015(2015)
• Publication Date: 2015-11-16
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2015/754931
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : In the present study, a 50% ethanolic extract of Orthosiphon stamineus was tested for its α -glucosidase inhibitory activity. In vivo assays of the extract (containing 1.02%, 3.76%, and 3.03% of 3′hydroxy-5, 6, 7, 4′-tetramethoxyflavone, sinensetin, and eupatorin, resp.) showed that it possessed an inhibitory activity against α -glucosidase in normal rats loaded with starch and sucrose. The results showed that 1000 mg/kg of the 50% ethanolic extract of O. stamineus significantly (P < 0.05 ) decreased the plasma glucose levels of the experimental animals in a manner resembling the effect of acarbose. In streptozotocin-induced diabetic rats, only the group treated with 1000 mg/kg of the extract showed significantly (P < 0.05 ) lower plasma glucose levels after starch loading. Hence, α -glucosidase inhibition might be one of the mechanisms by which O. stamineus extract exerts its antidiabetic effect. Furthermore, our findings indicated that the 50% ethanolic extract of O. stamineus can be considered as a potential agent for the management of diabetes mellitus.