MoMuLV-ts-1: A Unique Mouse Model of Retrovirus-Induced Lymphoma Transmitted by Breast Milk. (16th August 2011)

• Record Type: Journal Article
• Authors: Chakraborty, J.; Okonta, H.; Bagalb, H.; Duggan, J.
• Other Names: Jolicoeur Paul Academic Editor.
• Is Part Of: Advances in virology. Volume 2011(2011)
• Publication Date: 2011-08-16
• Subjects: Virology -- Periodicals; 616.9101
• DOI: 10.1155/2011/813651
• Languages: English
• ISSNs: 1687-8639

Abstract

Abstract : Our laboratory has developed a murine model of lymphoma via breast milk transmission of MoMuLV-ts-1 (Moloney murine leukemia virus-temperature sensitive mutant-1). Uninfected offspring suckled from infected surrogate mothers become infected and develop lymphoma. Multiple gene integration sites of ts-1 into the infected mouse genome including tacc3, aurka, ndel1, tpx2, p53, and rhamm were identified, and mRNA expressions were quantitated. These genes produce centrosomal proteins, which may be involved in abnormal chromosomal segregation leading to aneuploidy or multiploidy, thus causing lymphoma. Since there is no report to date on this retroviral model leading to centrosomal abnormality, and causing lymphoma development, this is a valuable and unique model to study the centrosomal involvement in lymphomagenesis.