Novel Roles of the Picornaviral 3D Polymerase in Viral Pathogenesis. (14th June 2010)

• Record Type: Journal Article
• Authors: Kerkvliet, Jason; Edukulla, Ramakrishna; Rodriguez, Moses
• Other Names: Pavlakis George N. Academic Editor.
• Is Part Of: Advances in virology. Volume 2010(2010)
• Publication Date: 2010-06-14
• Subjects: Virology -- Periodicals; 616.9101
• DOI: 10.1155/2010/368068
• Languages: English
• ISSNs: 1687-8639

Abstract

Abstract : The RNA-dependent RNA-polymerase, 3 D pol, is an essential component in the picornavirus genome for the replication of single stranded RNA. However, transgenic expression of3 D pol in mice has antiviral effects. Here, we discuss the structure and function of3 D pol during picornavirus replication, we review the evidence and consequence of a host immune response to epitopes in3 D pol after picornavirus infection, highlight data showing the antiviral effects of transgenic3 D pol from Theiler's murine encephalomyelitis virus (TMEV), and discuss potential mechanisms by which3 D pol is causing this antiviral effect in mice.