BF3·Et2O Catalysed 4-Aryl-3-phenyl-benzopyrones, Pro-SERMs, and Their Characterization. (1st September 2015)

• Record Type: Journal Article
• Authors: Srivastava, Ambika; Singh, Pooja; Kumar, Rajesh
• Other Names: Skaar Todd C. Academic Editor.
• Is Part Of: Advances in pharmacological sciences. Volume 2015(2015)
• Publication Date: 2015-09-01
• Subjects: Pharmacology -- Periodicals; Pharmacological Phenomena; Pharmacology; Periodicals; 615.1
• DOI: 10.1155/2015/527159
• Languages: English
• ISSNs: 1687-6334

Abstract

Abstract : We have synthesized the novel 4-(4-hydroxy-benzyl)-3-phenyl-chromen-2-one which is a precursor of SERMs with a smaller number of steps and good yield. Two methodologies for the synthesis have been worked out. Anhydrous BF3 ·Et2 O catalyzed reaction was found to be selective for product formation while anhydrous AlCl3, FeCl3, and SnCl4 catalyzed ones were nonselective.