Biomarkers of Oxidative Stress and Personalized Treatment of Pulmonary Tuberculosis: Emerging Role of Gamma-Glutamyltransferase. (7th May 2012)

• Record Type: Journal Article
• Authors: Mokondjimobe, Etienne; Longo-Mbenza, Benjamin; Akiana, Jean; Ndalla, Ulrich Oswald; Dossou-Yovo, Regis; Mboussa, Joseph; Parra, Henri-Joseph
• Other Names: Omri Abdelwahab Academic Editor.
• Is Part Of: Advances in pharmacological sciences. Volume 2012(2012)
• Publication Date: 2012-05-07
• Subjects: Pharmacology -- Periodicals; Pharmacological Phenomena; Pharmacology; Periodicals; 615.1
• DOI: 10.1155/2012/465634
• Languages: English
• ISSNs: 1687-6334

Abstract

Abstract : Background . The objectives were (i) to evaluate the impact of acute pulmonary tuberculosis (PTB) and anti-TB therapy on the relationship between AST, ALT, and GGT levels in absence of conditions related to hepatotoxicity; (ii) to evaluate the rate and the time of alterations of AST, ALT, and GGT. Design and Methods . A prospective followup of 40 adults (21 males; mean age of34.7 ± 5.8 years) with active PTB on initial phase and continuation phase anti-TB. Results . Only 3% (n = 1 ) developed a transient and benign ADR at day 30 without interruption of anti-TB treatment. Within normal ranges, GGT decreased significantly from day 0 to day 60, while AST and ALT increased significantly and respectively. During day 0–day 60, there was a significant, negative, and independent association between GGT and AST. Conclusion . The initial two months led to significant improvement of oxidative stress. Values of oxidative markers in normal ranges might predict low rate of ADR.