A Review of the Receptor-Binding Properties of p-Synephrine as Related to Its Pharmacological Effects. (28th June 2011)

• Record Type: Journal Article
• Authors: Stohs, Sidney J.; Preuss, Harry G.; Shara, Mohd
• Other Names: Khaper Neelam Academic Editor.
• Is Part Of: Oxidative medicine and cellular longevity. Volume 2011(2011)
• Publication Date: 2011-06-28
• Subjects: Oxidative stress -- Periodicals; Cells -- Aging -- Periodicals; Cells -- Aging; Oxidative stress; Oxidative Stress -- Periodicals; Cell Aging -- Periodicals; Periodicals; 611.0181
• DOI: 10.1155/2011/482973
• Languages: English
• ISSNs: 1942-0900

Abstract

Abstract : Bitter orange ( Citrus aurantium ) extract and its primary protoalkaloid p -synephrine are used widely in weight loss/weight management and sports performance products. Because of structural similarities, the pharmacological effects of p -synephrine are widely assumed to be similar to those of ephedrine, m -synephrine (phenylephrine), and endogenous amine neurotransmitters as norepinephrine and epinephrine. However, small structural changes result in the receptor binding characteristics of these amines that are markedly different, providing a plausible explanation for the paucity of adverse effects associated with the wide-spread consumption of p -synephrine in the form of dietary supplements as well as in various Citrus foods and juices. This paper summarizes the adrenoreceptor binding characteristics of p -synephrine relative to m -synephrine, norepinephrine, and other amines as related to the observed pharmacological effects.