Intertoe Squamous Cell Carcinoma Developed in a Patient with Rheumatoid Arthritis under Etanercept Therapy. (1st March 2015)

• Record Type: Journal Article
• Authors: Rallis, Efstathios; Bournia, Vasiliki-Kalliopi; Verros, Constantinos; Iliopoulos, Alexios
• Other Names: Nesland Jahn M. Academic Editor.
• Is Part Of: Case reports in medicine. Volume 2015(2015)
• Publication Date: 2015-03-01
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Case Reports; Periodicals; 610
• DOI: 10.1155/2015/315490
• Languages: English
• ISSNs: 1687-9627

Abstract

Abstract : The use of tumor necrosis factor- α (TNF- α ) inhibitors in the treatment of various inflammatory conditions has altered the field of medical therapeutics. Squamous cell carcinoma is the second most common cancer of the skin, usually affecting sun-exposed areas of the body. We present here the case of a 75-year-old woman with rheumatoid arthritis, who developed an intertoe squamous cell carcinoma (SCC) of the right foot. According to her history, she received etanercept and methotrexate for 5 years for rheumatoid arthritis. The rare localization of this cancer could suggest a possible linkage of the malignancy to the chronic intake of anti-TNF- α treatment. This is the first reported case of an interdigital SCC developed under the use of an anti-TNF- α agent.