Cowden Syndrome and Concomitant Pulmonary Neuroendocrine Tumor: A Presentation of Two Cases. (22nd December 2015)

• Record Type: Journal Article
• Authors: Langer, Seppo W.; Ringholm, Lene; Dali, Christine I.; Petersen, Rene Horsleben; Rasmussen, Åse Krogh; Gerdes, Anne-Marie; Federspiel, Birgitte; Knigge, Ulrich Peter
• Other Names: Keck Tobias Academic Editor.
• Is Part Of: Case reports in medicine. Volume 2015(2015)
• Publication Date: 2015-12-22
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Case Reports; Periodicals; 610
• DOI: 10.1155/2015/265786
• Languages: English
• ISSNs: 1687-9627

Abstract

Abstract : Cowden Syndrome is a rare autosomal dominantly inherited disorder. Patients with Cowden Syndrome are at increased risk of various benign and malignant neoplasms in breast, endometrium, thyroid, gastrointestinal tract, and genitourinary system. Neuroendocrine tumors are ubiquitous neoplasms that may occur anywhere in the human body. Bronchopulmonary neuroendocrine tumors include four different histological subtypes, among these, typical and atypical pulmonary carcinoids. No association between Cowden Syndrome and neuroendocrine tumors has previously been described. We present two cases of Cowden Syndrome that were diagnosed with pulmonary carcinoids.