Stemness-Attenuating miR-503-3p as a Paracrine Factor to Regulate Growth of Cancer Stem Cells. (4th April 2018)

• Record Type: Journal Article
• Authors: Seo, Minkoo; Kim, Seung Min; Woo, Eun Young; Han, Ki-Cheol; Park, Eun Joo; Ko, Seongyeol; Choi, Eun wook; Jang, Mihue
• Other Names: Basak Pratima Academic Editor.
• Is Part Of: Stem cells international. Volume 2018(2018)
• Publication Date: 2018-04-04
• Subjects: Stem Cells -- Periodicals; Stem Cells -- Therapeutic use -- Periodicals; Stem Cells -- Transplantation -- Periodicals; 616.0277405
• DOI: 10.1155/2018/4851949
• Languages: English
• ISSNs: 1687-966X

Abstract

Abstract : Cancer stem cells (CSCs) with self-renewal abilities endorse cellular heterogeneity, resulting in metastasis and recurrence. However, there are no promising therapeutics directed against CSCs. Herein, we found that miR-503-3p inhibited tumor growth via the regulation of CSC proliferation and self-renewal. miR-503-3p, isolated from human adipose stem cell- (ASC-) derived exosomes, suppressed initiation and progression of CSCs as determined by anchorage-dependent (colony formation) and anchorage-independent (tumorsphere formation) assays. The expression of pluripotency genes was significantly decreased in miR-503-3p-treated CSCs. Furthermore, xenografts, which received miR-503-3p, exhibited remarkably reduced tumor growth in vivo . Thus, miR-503-3p may function as a stemness-attenuating factor via cell-to-cell communications.