Photodynamic Therapy with the Silicon Phthalocyanine Pc 4 Induces Apoptosis in Mycosis Fungoides and Sezary Syndrome. (17th October 2010)

• Record Type: Journal Article
• Authors: Lam, Minh; Lee, YooJin; Deng, Min; Hsia, Andrew H.; Morrissey, Kelly A.; Yan, Chunlin; Azzizudin, Kashif; Oleinick, Nancy L.; McCormick, Thomas S.; Cooper, Kevin D.; Baron, Elma D.
• Other Names: Peschel Christian Academic Editor.
• Is Part Of: Advances in hematology. Volume 2009(2009)
• Publication Date: 2010-10-17
• Subjects: Hematology -- Periodicals; Hematologic Diseases; Hematology; Hematology; Periodicals; Periodicals; 616.15
• DOI: 10.1155/2010/896161
• Languages: English
• ISSNs: 1687-9104

Abstract

Abstract : Our current focus on the effects of Photodynamic Therapy (PDT) using silicon phthalocyanine Pc 4 photosensitizer on malignant T lymphocytes arose due to preclinical observations that Jurkat cells, common surrogate for human T cell lymphoma, were more sensitive to Pc 4-PDT-induced killing than epidermoid carcinoma A431 cells. Mycosis fungoides (MF) as well as Sezary syndrome (SS) are variants of cutaneous T-cell lymphoma (CTCL) in which malignant T-cells invade the epidermis. In this study, we investigated the cytotoxicity of Pc 4-PDT in peripheral blood cells obtained from patients with SS and in skin biopsies of patients with MF. Our data suggest that Pc 4-PDT preferentially induces apoptosis of CD4 + CD7 − malignant T-lymphocytes in the blood relative to CD11b + monocytes and nonmalignant T-cells. In vivo Pc 4-PDT of MF skin also photodamages the antiapoptotic protein Bcl-2.