Antibacterial Membrane with a Bone-Like Structure for Guided Bone Regeneration. (21st September 2015)

• Record Type: Journal Article
• Authors: Zhang, YuYuan; Mao, WeiJia; Wang, Jian; Li, Quan-Li; Mei, May Lei; Chu, Chun Hung; Xia, Rong; Zhang, Zhi-Hong
• Other Names: Castaño Victor M. Academic Editor.
• Is Part Of: Journal of nanomaterials. Volume 2015(2015)
• Publication Date: 2015-09-21
• Subjects: Nanostructured materials -- Periodicals; Nanotechnology -- Periodicals; Nanomatériaux; Nanostructured materials; Nanotechnology; Nanostructures; Nanotechnology; Periodicals; Fulltext; Internet Resources; Periodicals; 620.115
• DOI: 10.1155/2015/784574
• Languages: English
• ISSNs: 1687-4110

Abstract

Abstract : An antibacterial membrane with a bone-like structure was developed for guided bone regeneration (GBR) by mineralising acellular bovine pericardium (ABP) and loading it with the antibiotic minocycline. The bovine pericardium (BP) membrane was processed using physical and chemical methods to remove the cellular components and obtain ABP membranes. Then, the ABP membranes were biomimetically mineralised using a calcium phosphate-loaded agarose hydrogel system aided by electrophoresis. Minocycline was adsorbed to the mineralised ABP membrane, and the release profile in vitro was studied. The membranes were characterised through scanning electron microscopy, diffuse reflectance-Fourier transform infrared spectroscopy, and X-ray diffraction. Results showed that the ABP membrane had an asymmetric structure with a layer of densely arranged and irregularly aligned collagen fibrils. Collagen fibrils were calcified with the formation of intrafibrillar and interfibrillar hydroxyapatites similar to the bone structure. Minocycline was incorporated into the mineralised collagen membrane and could be released in vitro. This process endowed the membrane with an antibacterial property. This novel composite membrane offers promising applications in bioactive GBR.