Evaluation of Factor VIII as a Risk Factor in Indian Patients with DVT. (1st September 2015)

• Record Type: Journal Article
• Authors: Hazra, Darpanarayan; Sen, Indrani; Stephen, Edwin; Agarwal, Sunil; Nair, Sukesh Chandran; Mammen, Joy
• Other Names: Matsagkas Miltiadis I. Academic Editor.
• Is Part Of: Surgery research and practice. Volume 2015(2015)
• Publication Date: 2015-09-01
• Subjects: Surgery -- Periodicals; 617.005
• DOI: 10.1155/2015/307879
• Languages: English
• ISSNs: 2356-7759

Abstract

Abstract : Introduction . Elevated factor VIII population in the Indian population has not been studied as a possible risk factor for deep vein thrombosis (DVT). High factor VIII level is considered a predisposing factor for DVT and its recurrence. However it is known to vary between populations and its exact role in the etiopathogenesis of thrombophilia remains unknown. Material and Methods . Factor VIII levels of patients with DVT who had undergone a prothrombotic workup as a part of their workup was compared to normal age matched controls in a 1 : 3 ratio. Results . There were 75 patients with DVT who had undergone a prothrombotic workup in the course of their treatment for lower limb DVT. In these, 64% had levels of factor VIII more than 150 as compared to 63% of normal controls (p > 0 . 05, not significant). Conclusion . Elevated factor VIII in the Indians may not be associated with the same thrombotic risk as seen in the West. We find a variation in the levels of factor VIII with a different "normal" than what is reported in other populations. This needs further study to elucidate the role of factor VIII in the evaluation and treatment of thrombophilia.