Polymer-Stabilized Micelles Reduce the Drug Rapid Clearance In Vivo. (22nd May 2018)

• Record Type: Journal Article
• Authors: Wen, Shan-Ni; Chu, Chih-Hang; Wang, Yu-Chao; Huang, Hsin-Ying; Wang, Yu-Jing; Lin, Jia-Yi; Lu, Hsiao-Ting; Wang, Sin-Jie; Yang, Chung-Shi
• Other Names: Bellucci Stefano Academic Editor.
• Is Part Of: Journal of nanomaterials. Volume 2018(2018)
• Publication Date: 2018-05-22
• Subjects: Nanostructured materials -- Periodicals; Nanotechnology -- Periodicals; Nanomatériaux; Nanostructured materials; Nanotechnology; Nanostructures; Nanotechnology; Periodicals; Fulltext; Internet Resources; Periodicals; 620.115
• DOI: 10.1155/2018/5818592
• Languages: English
• ISSNs: 1687-4110

Abstract

Abstract : Micelles are self-assembled nanoscaled aggregates from amphiphilic unimers and can be used to encapsulate hydrophobic drugs. However, the dynamic exchanging of unimers between micelles and bulk solution often leads to micelle destabilization and subsequent leaking of the encapsulated substances. Thus, we incorporated a hydrophobic polymer into the micellar core for interlacing the unimers and stabilizing the micelle structure. The polymer-stabilized and non-polymer-stabilized micelles have similar physicochemical properties including small sizes (~35 nm), negative surface charges (~−35 mV), and high drug contents (~15%). Drugs encapsulated in polymer-stabilized micelles are released in a slower rate than are non-polymer-stabilized micelles. From in vivo pharmacokinetic studies, drugs loaded in polymer-stabilized micelles have lower clearance and higher plasma concentration and lower volume distribution than non-polymer-stabilized micelles have. In conclusion, polymer-stabilized micelles can reduce rapid drug clearance via strengthening of the micellar structure and increase in the available drug amount in plasma, thus broadening pharmaceutical applications of micelles.