Doxorubicin-Loaded Melanin Particles for Enhanced Chemotherapy in Drug-Resistant Anaplastic Thyroid Cancer Cells. (11th February 2018)

• Record Type: Journal Article
• Authors: Wang, Kun; Wang, Shouju; Chen, Kun; Zhao, Yijing; Ma, Xingqun; Wang, Lin
• Other Names: Vazquez Ester Academic Editor.
• Is Part Of: Journal of nanomaterials. Volume 2018(2018)
• Publication Date: 2018-02-11
• Subjects: Nanostructured materials -- Periodicals; Nanotechnology -- Periodicals; Nanomatériaux; Nanostructured materials; Nanotechnology; Nanostructures; Nanotechnology; Periodicals; Fulltext; Internet Resources; Periodicals; 620.115
• DOI: 10.1155/2018/2603712
• Languages: English
• ISSNs: 1687-4110

Abstract

Abstract : Anaplastic thyroid cancer (ATC) is highly aggressive and tends to develop drug resistance to standard chemotherapies. To overcome the drug resistance of ATC, we synthesized dopamine-melanin nanoparticles (MNPs) loaded with doxorubicin (Dox) molecules. The Dox-loaded MNPs (Dox-MNPs) developed exhibited increased cellular uptake and enhanced therapeutic efficacy in drug-resistant ATC cell line HTh74R, compared with free Dox. The native MNPs were found to have excellent biocompatibility, which suggests that Dox-MNPs may have potential in the treatment of ATC.