Technological Progress in Generation of Induced Pluripotent Stem Cells for Clinical Applications. (12th March 2012)

• Record Type: Journal Article
• Authors: Oh, Seung-Ick; Lee, Chang Kyu; Cho, Kyung Jin; Lee, Kyung-Ok; Cho, Ssang-Goo; Hong, Sunghoi
• Other Names: Bai Yidong Academic Editor.; Dricu Anica Academic Editor.
• Is Part Of: TheScientificWorldjournal. Volume 2012(2012)
• Publication Date: 2012-03-12
• Subjects: Science -- Periodicals; Technology -- Periodicals; Medicine -- Periodicals; 505
• DOI: 10.1100/2012/417809
• Languages: English
• ISSNs: 2356-6140

Abstract

Abstract : Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is achieved by viral-mediated transduction of defined transcription factors. Generation of iPSCs is of great medical interest as they have the potential to be a source of patient-specific cells. For the eventual goal of clinical application, it is necessary to overcome the limitations of low reprogramming efficiency and chromosomal abnormalities due to viral DNA integration. In this paper, we summarize the current state of reprogramming technology for generation of iPSCs and also discuss potential approaches to the development of safe iPSCs for personalized cell-based replacement therapy.