14-3-3 Proteins in Glutamatergic Synapses. (23rd April 2018)

• Record Type: Journal Article
• Authors: Zhang, Jiajing; Zhou, Yi
• Other Names: Galdzicki Zygmunt Academic Editor.
• Is Part Of: Neural plasticity. Volume 2018(2018)
• Publication Date: 2018-04-23
• Subjects: Neuroplasticity -- Periodicals; 612.82
• DOI: 10.1155/2018/8407609
• Languages: English
• ISSNs: 2090-5904

Abstract

Abstract : The 14-3-3 proteins are a family of proteins that are highly expressed in the brain and particularly enriched at synapses. Evidence accumulated in the last two decades has implicated 14-3-3 proteins as an important regulator of synaptic transmission and plasticity. Here, we will review previous and more recent research that has helped us understand the roles of 14-3-3 proteins at glutamatergic synapses. A key challenge for the future is to delineate the 14-3-3-dependent molecular pathways involved in regulating synaptic functions.