New Oral Anticoagulants for Thromboprophylaxis after Elective Total Hip and Knee Arthroplasty. (29th June 2010)

• Record Type: Journal Article
• Authors: Friedman, Richard J.
• Other Names: Palareti Gualtiero Academic Editor.
• Is Part Of: Thrombosis. Volume 2010(2010)
• Publication Date: 2010-06-29
• Subjects: Thrombosis -- Periodicals; Thrombosis; Thrombosis; Electronic journals; Periodical; Electronic journals; Periodicals; 616.135
• DOI: 10.1155/2010/280731
• Languages: English
• ISSNs: 2090-1488

Abstract

Abstract : Anticoagulant drugs reduce the risk of venous thromboembolic events after total hip and knee arthroplasty. However, the use of current drugs, such as low molecular weight heparins, is hampered by their subcutaneous route of administration. The use of vitamin K antagonists is hampered by the requirement for routine coagulation monitoring and dose titration to provide effective anticoagulation without an increased risk of bleeding and numerous food and drug interactions. Clearly, there is a need for new oral, fixed-dose anticoagulant drugs that do not require coagulation monitoring, while demonstrating similar or better efficacy and safety profiles when compared with current agents.