Effects of Acute Normovolemic Anemia on Hemodynamic Parameters and Acid-Base Balance in Dogs. (30th March 2011)

• Record Type: Journal Article
• Authors: Champion, Tatiana; Pereira Neto, Glaucia Bueno; Camacho, Aparecido Antonio
• Other Names: Lobetti Remo G. Academic Editor.
• Is Part Of: Veterinary medicine international. Volume 2011(2011)
• Publication Date: 2011-03-30
• Subjects: Veterinary medicine -- Periodicals; Veterinary Medicine; Veterinary medicine; Periodicals; Periodicals; 636.089
• DOI: 10.4061/2011/829054
• Languages: English
• ISSNs: 2090-8113

Abstract

Abstract : The aim of this study was to evaluate the hemodynamic and acid-base status of dogs subjected to acute normovolemic anemia. The dogs (n = 10 ) were evaluated 15 minutes and 24 hours after induction of anemia (hematocrit below 18%) with blood withdrawal and simultaneously replacement of same volume of Ringer's lactate solution and hydroxyethyl starch-based solution in a 2 : 1 ratio. The cardiac output was measured by Doppler echocardiography and blood pressure by oscillometric device, and posteriorly hemodynamic parameters were calculated. The anemic groups had increase in cardiac index( P < .05 ) (3.82 ± 1.05 to5.86 ± 1.49 and5.81 ± 1.63 L/min × m 2 ) and decreases( P < .05 ) in the indices of total peripheral resistance (6797.81 ± 3060.22 to3220.14 ± 1275.02 and3887.74 ± 1394.89 dina·seg/cm 5 × m 2 ) and oxygen delivery (7942.84 ± 3344.00 to4021.68 ± 1627.00 and4430.82 ± 1402.61 mL/min × m 2 ), respectively. There were no significant changes in pH, but PaO2 and SaO2 values were increased, and PaCO2 reduced in anemic dogs( P < .05 ) . Therefore, acute normovolemic anemia can create significant hemodynamic changes and despite some hemogasometric changes, there were no changes in the acid-base status in dogs.