Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of Mycobacterium tuberculosis. (22nd March 2011)

• Record Type: Journal Article
• Authors: Baquero, Eduard; Quiñones, Wiston; Ribon, Wellman; Caldas, Maria Leonor; Sarmiento, Ladys; Echeverri, Fernando
• Other Names: Eley Brian Academic Editor.
• Is Part Of: Tuberculosis research and treatment. Volume 2011(2011)
• Publication Date: 2011-03-22
• Subjects: Tuberculosis -- Periodicals; Tuberculosis -- Prevention -- Periodicals; Tuberculosis -- Treatment -- Periodicals; Tuberculosis -- Social aspects -- Periodicals; 616.995005
• DOI: 10.1155/2011/986409
• Languages: English
• ISSNs: 2090-150X

Abstract

Abstract : Tuberculosis (TB) is an important disease that causes thousands of deaths around the world. Resistance against antitubercular available drugs has been reported; so, research on new effective antimycobacterial molecules is needed. Antimycobacterial activity of three lignans and two synthetic hydrazones was assessed against Mycobacterium tuberculosis H37Rv by antimycobacterial microdilution assay (TEMA). An oxadiazoline (AC451) and a lignan (ethoxycubebin) were the most active compounds (MIC 6.09 and 62.4 μ M, resp.). Several changes in mycolic acid profile of treated bacteria were detected with both compounds by mass spectrometry analysis. Additionally, the level of reduction of mycolic acids in ethoxycubebin treatment was correlated to disruption in bacterial morphology.