Haploidentical Stem Cell Transplantation in Adult Haematological Malignancies. (30th May 2016)

• Record Type: Journal Article
• Authors: Parmesar, Kevon; Raj, Kavita
• Other Names: Chakrabarti Suparno Academic Editor.
• Is Part Of: Advances in hematology. Volume 2016(2016)
• Publication Date: 2016-05-30
• Subjects: Hematology -- Periodicals; Hematologic Diseases; Hematology; Hematology; Periodicals; Periodicals; 616.15
• DOI: 10.1155/2016/3905907
• Languages: English
• ISSNs: 1687-9104

Abstract

Abstract : Haematopoietic stem cell transplantation is a well-established treatment option for both hematological malignancies and nonmalignant conditions such as aplastic anemia and haemoglobinopathies. For those patients lacking a suitable matched sibling or matched unrelated donor, haploidentical donors are an alternative expedient donor pool. Historically, haploidentical transplantation led to high rates of graft rejection and GVHD. Strategies to circumvent these issues include T cell depletion and management of complications thereof or T replete transplants with GVHD prophylaxis. This review is an overview of these strategies and contemporaneous outcomes for hematological malignancies in adult haploidentical stem cell transplant recipients.