Role of C-Peptide in the Regulation of Microvascular Blood Flow. (28th July 2008)

• Record Type: Journal Article
• Authors: Forst, T.; Kunt, T.; Wilhelm, B.; Weber, M. M.; Pfützner, A.
• Other Names: King George Academic Editor.
• Is Part Of: Experimental diabetes research. Volume 2008(2008)
• Publication Date: 2008-07-28
• Subjects: Diabetes -- Research -- Periodicals; Diabetes -- Research; Periodicals; 616.462
• DOI: 10.1155/2008/176245
• Languages: English
• ISSNs: 1687-5214

Abstract

Abstract : During the recent years, the role of C-peptide, released from the pancreatic beta cell, in regulating microvascular blood flow, has received increasing attention. In type 1 diabetic patients, intravenous application of C-peptide in physiological concentrations was shown to increase microvascular blood flow, and to improve microvascular endothelial function and the endothelial release of NO. C-peptide was shown to impact microvascular blood flow by several interactive pathways, like stimulatingNa + K + ATPase or the endothelial release of NO. There is increasing evidence, that in patients with declining beta cell function, the lack of C-peptide secretion might play a putative role in the development of microvascular blood flow abnormalities, which go beyond the effects of declining insulin secretion or increased blood glucose levels.