Nonsurgical Transurethral Radiofrequency Collagen Denaturation: Results at Three Years after Treatment. (5th December 2010)

• Record Type: Journal Article
• Authors: Elser, Denise M.; Mitchell, Gretchen K.; Miklos, John R.; Nickell, Kevin G.; Cline, Kevin; Winkler, Harvey; Wells, W. Glen
• Other Names: Brown James A. Academic Editor.
• Is Part Of: Advances in urology. Volume 2011(2011)
• Publication Date: 2010-12-05
• Subjects: Urology -- Periodicals; 616.6005
• DOI: 10.1155/2011/872057
• Languages: English
• ISSNs: 1687-6369

Abstract

Abstract : Objective . To assess treatment efficacy and quality of life in women with stress urinary incontinence 3 years after treatment with nonsurgical transurethral radiofrequency collagen denaturation. Methods . This prospective study included 139 women with stress urinary incontinence due to bladder outlet hypermobility. Radiofrequency collagen denaturation was performed using local anesthesia in an office setting. Assessments included incontinence quality of life (I-QOL) and urogenital distress inventory (UDI-6) instruments. Results . In total, 139 women were enrolled and 136 women were treated (mean age, 47 years). At 36 months, intent-to-treat analysis (n = 139 ) revealed significant improvements in quality of life. Mean I-QOL score improved 17 points from baseline (P = .0004 ), while mean UDI-6 score improved (decreased) 19 points (P = .0005 ). Conclusions . Transurethral collagen denaturation is a low-risk, office-based procedure that results in durable quality-of-life improvements in a significant proportion of women for as long as 3 years.