Clinical and Experimental Evidences of Hydrogen Sulfide Involvement in Lead-Induced Hypertension. (28th March 2018)

• Record Type: Journal Article
• Authors: Possomato-Vieira, José Sérgio; Gonçalves-Rizzi, Victor Hugo; Nascimento, Regina Aparecida do; Wandekin, Rodrigo Roldão; Caldeira-Dias, Mayara; Chimini, Jessica Sabbatine; da Silva, Maria Luiza Santos; Dias-Junior, Carlos A.
• Other Names: Lu Wan-Liang Academic Editor.
• Is Part Of: BioMed research international. Volume 2018(2018)
• Publication Date: 2018-03-28
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2018/4627391
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Lead- (Pb-) induced hypertension has been shown in humans and experimental animals and cardiovascular effects of hydrogen sulfide (H2 S) have been reported previously. However, no studies examined involvement of H2 S in Pb-induced hypertension. We found increases in diastolic blood pressure and mean blood pressure in Pb-intoxicated humans followed by diminished H2 S plasmatic levels. In order to expand our findings, male Wistar rats were divided into four groups: Saline, Pb, NaHS, and Pb + NaHS. Pb-intoxicated animals received intraperitoneally (i.p.) 1st dose of 8 μ g/100 g of Pb acetate and subsequent doses of 0.1 μ g/100 g for seven days and sodium hydrosulfide- (NaHS-) treated animals received i.p. NaHS injections (50 μ mol/kg/twice daily) for seven days. NaHS treatment blunted increases in systolic blood pressure, increased H2 S plasmatic levels, and diminished whole-blood lead levels. Treatment with NaHS in Pb-induced hypertension seems to induce a protective role in rat aorta which is dependent on endothelium and seems to promote non-NO-mediated relaxation. Pb-intoxication increased oxidative stress in rats, while treatment with NaHS blunted increases in plasmatic MDA levels and increased antioxidant status of plasma. Therefore, H2 S pathway may be involved in Pb-induced hypertension and treatment with NaHS exerts antihypertensive effect, promotes non-NO-mediated relaxation, and decreases oxidative stress in rats with Pb-induced hypertension.