Effect of Low and High Dose Sugammadex on the Coagulation and Fibrinolytic System in Rats. (7th June 2015)

• Record Type: Journal Article
• Authors: Taş, Nilay; Yağan, Özgür; Noyan, Tevfik; Ayyıldız, Sema Nur; Üstün, Y. Burcu; Gözlükaya, Özgül; Kocamanoğlu, Serhat
• Other Names: Shyr Ming-Hwang Academic Editor.
• Is Part Of: Advances in anesthesiology. (2015)
• Publication Date: 2015-06-07
• Subjects: Anesthesiology -- Periodicals; Anesthesiology; Periodicals; 617.96
• DOI: 10.1155/2015/708915
• Languages: English
• ISSNs: 2356-6574

Abstract

Abstract : Background . Sugammadex is a new reversal agent that has entered use recently. It is known that with sugammadex some changes in coagulation parameters occur without documented clinical results. Aim of the Work . The objective of this study was to identify effects of sugammadex on liver functions, coagulation, and fibrinolytic systems. Methods . Thirty-six rats were randomized into six groups: Group I, control; Group II, rocuronium group; Group III, sugammadex administered in 16 mg kg −1 dose; Group IV, sugammadex administered in 96 mg kg −1 dose; Group V, rocuronium and sugammadex administered in 16 mg kg −1 dose; and Group VI, rocuronium and sugammadex administered in 96 mg kg −1 dose. After 120 minutes, blood samples were obtained for prothrombin time, activated partial thromboplastin time, D-dimer, fibrinogen, aspartate aminotransferase, alanine aminotransferase, albumin, platelet, and mean platelet volume analyses. Results . Compared to the control group, in all groups measured parameters did not show any effect from a statistical viewpoint either due to the administered drugs alone or due to interaction effects. Conclusion . The conclusion was reached that administration of sugammadex in rats did not have any significant effect on the fibrinolytic system, coagulation parameters, and liver function.