Research Progress on the Animal Models of Drug-Induced Liver Injury: Current Status and Further Perspectives. (15th April 2019)

• Record Type: Journal Article
• Authors: Pan, Yingying; Cao, Mingzhu; You, Danming; Qin, Genggeng; Liu, Zhi
• Other Names: Jadeja Ravirajsinh N. Academic Editor.
• Is Part Of: BioMed research international. Volume 2019(2019)
• Publication Date: 2019-04-15
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2019/1283824
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Drug-induced liver injury (DILI) is a major concern in clinical studies as well as in postmarketing surveillance. It is necessary to establish an animal model of DILI for thorough investigation of mechanisms of DILI and searching for protective medications. This article reviews the current status and future perspective on establishment of DILI models based on different hepatotoxic drugs, as well as the underlying mechanisms of liver function damage induced by specific medicine. Therefore, information from this article can help researchers make a suitable selection of animal models for further study.