Strong Expression of Chemokine Receptor CXCR4 by Renal Cell Carcinoma Correlates with Advanced Disease. (30th December 2008)

• Record Type: Journal Article
• Authors: Wehler, Thomas C.; Graf, Claudine; Biesterfeld, Stefan; Brenner, Walburgis; Schadt, Jörg; Gockel, Ines; Berger, Martin R.; Thüroff, Joachim W.; Galle, Peter R.; Moehler, Markus; Schimanski, Carl C.
• Other Names: Herlyn Meenhard Academic Editor.
• Is Part Of: Journal of oncology. Volume 2008(2008)
• Publication Date: 2008-12-30
• Subjects: Oncology -- Research -- Periodicals; Tumors -- Periodicals; Neoplasms; Oncology -- Research; Tumors; Periodicals; Periodicals; 616.994
• DOI: 10.1155/2008/626340
• Languages: English
• ISSNs: 1687-8450

Abstract

Abstract : Diverse chemokines and their receptors have been associated with tumor growth, tumor dissemination, and local immune escape. In different tumor entities, the level of chemokine receptor CXCR 4 expression has been linked with tumor progression and decreased survival. The aim of this study was to evaluate the influence of CXCR 4 expression on the progression of human renal cell carcinoma. CXCR 4 expression of renal cell carcinoma was assessed by immunohistochemistry in 113 patients. Intensity of CXCR 4 expression was correlated with both tumor and patient characteristics. Human renal cell carcinoma revealed variable intensities of CXCR 4 expression. Strong CXCR 4 expression of renal cell carcinoma was significantly associated with advanced T-status (P = .039 ), tumor dedifferentiation ( P = .0005), and low hemoglobin ( P = .039). In summary, strong CXCR 4 expression was significantly associated with advanced dedifferentiated renal cell carcinoma.