Cancer Malignancy Is Enhanced by Glyceraldehyde-Derived Advanced Glycation End-Products. (28th June 2010)

• Record Type: Journal Article
• Authors: Takino, Jun-Ichi; Yamagishi, Sho-Ichi; Takeuchi, Masayoshi
• Other Names: Mulshine James L. Academic Editor.
• Is Part Of: Journal of oncology. Volume 2010(2010)
• Publication Date: 2010-06-28
• Subjects: Oncology -- Research -- Periodicals; Tumors -- Periodicals; Neoplasms; Oncology -- Research; Tumors; Periodicals; Periodicals; 616.994
• DOI: 10.1155/2010/739852
• Languages: English
• ISSNs: 1687-8450

Abstract

Abstract : The receptor for advanced glycation end-products (RAGEs) is associated with the malignancy of cancer. A recent study has suggested that glyceraldehyde-derived AGEs (Glycer-AGEs) enhanced the malignancy of melanoma cells, but glucose-derived AGEs did not. However, the effects of Glycer-AGEs on other cancer cells remain poorly understood, and the molecular mechanisms behind the above-mentioned effect have not been clarified. The present paper aimed to examine the effect of Glycer-AGEs on cultured lung cancer A549 cells. RAGE was expressed in A549 cells. Glycer-AGEs significantly attenuated cell proliferation. Furthermore, Glycer-AGEs enhanced the migration capacity of the cells by activating Rac1 via ROS and also increased their invasion capacity. We demonstrated that Glycer-AGEs enhanced the migration and invasion of A549 cells rather than their proliferation. These results suggest that Glycer-AGEs play a critical role in the malignancy of cancer rather than its proliferation and are potential targets for therapeutic intervention.