(+)-Z-Bisdehydrodoisynolic Acid Enhances Basal Metabolism and Fatty Acid Oxidation in Female Obese Zucker Rats. (1st March 2011)

• Record Type: Journal Article
• Authors: Banz, William J.; Strader, April D.; Ajuwon, Kolapo M.; Hou, Yuqing; Meyers, Cal Y.; Davis, Jeremy E.
• Other Names: Yanovski Jack A. Academic Editor.
• Is Part Of: Journal of obesity. Volume 2012(2012)
• Publication Date: 2011-03-01
• Subjects: Obesity -- Periodicals; Obesity; Obesity; Electronic journals; Periodicals; Periodicals; 616.398
• DOI: 10.1155/2012/154145
• Languages: English
• ISSNs: 2090-0708

Abstract

Abstract : We have previously reported that the synthetic estrogen, (+)- Z -bisdehydrodoisynolic Acid [(+)- Z -BDDA], attenuated weight gain and cardiovascular risk in obese rodents. To determine if these antiobesity effects were attributed to changes in basal metabolism, we assessed indirect calorimetry and metabolic profile in female obese Zucker (OZR) rats provided (+)- Z -BDDA (0.0002% food admixture) for 11 weeks. Similar to our previous findings, (+)- Z -BDDA reduced weight gain and improved lipid and glucose homeostasis in OZR rats. Furthermore, resting energy expenditure was increased by (+)- Z -BDDA, as evident by heat production and oxygen consumption. We also observed a marked reduction in respiratory quotient (RQ) along with a corresponding induction of hepatic AMPK in rodents provided (+)- Z -BDDA. Collectively, these findings indicate that (+)- Z -BDDA partially attenuated obesity and associated pathologies through increased resting energy expenditure and fatty acid utilization. Further investigation is required to fully elucidate the mechanisms involved as well as to determine the potential therapeutic implications for (+)- Z -BDDA on obesity and its related pathologies.