Hunting for genes that shape human faces: Initial successes and challenges for the future. (10th May 2019)

• Record Type: Journal Article
• Authors: Weinberg, Seth M.; Roosenboom, Jasmien; Shaffer, John R.; Shriver, Mark D.; Wysocka, Joanna; Claes, Peter
• Is Part Of: Orthodontics and craniofacial research. Volume 22:(2019)Supplement 1
• Page Start: 207
• Page End: 212
• Publication Date: 2019-05-10
• Subjects: complex genetic traits -- face shape -- genome‐wide association studies -- genotype‐phenotype correlation -- heritability -- normal‐range variation; Skull -- Growth -- Periodicals; Facial bones -- Growth -- Periodicals; Orthodontics -- Periodicals; Orthodontics, Corrective -- Periodicals; Orthodontic appliances -- Periodicals; 617.51
• DOI: 10.1111/ocr.12268
• Languages: English
• ISSNs: 1601-6335

Abstract

Structured Abstract: There is ample evidence from heritability studies, genetic syndromes and experimental animal models that facial morphology is strongly influenced by genes. In this brief review, we present an up‐to‐date overview of the efforts to identify genes associated with the size and shape of human facial features. We discuss recent methodological advances that have led to breakthroughs, but also the multitude of challenges facing the field. We offer perspective on possible applications of this line of research, particularly in the context of the precision genomics movement.