A Topological Description of Hubs in Amino Acid Interaction Networks. (26th May 2010)

• Record Type: Journal Article
• Authors: Gaci, Omar
• Other Names: Casadio Rita Academic Editor.
• Is Part Of: Advances in bioinformatics. Volume 2010(2010)
• Publication Date: 2010-05-26
• Subjects: Bioinformatics -- Periodicals; Bioinformatics; Computational Biology -- Periodicals; Periodicals; 570.285
• DOI: 10.1155/2010/257512
• Languages: English
• ISSNs: 1687-8027

Abstract

Abstract : We represent proteins by amino acid interaction networks. This is a graph whose vertices are the proteins amino acids and whose edges are the interactions between them. Once we have compared this type of graphs to the general model of scale-free networks, we analyze the existence of nodes which highly interact, the hubs. We describe these nodes taking into account their position in the primary structure to study their apparition frequency in the folded proteins. Finally, we observe that their interaction level is a consequence of the general rules which govern the folding process.