Mini EXPLORER II: a prototype high-sensitivity PET/CT scanner for companion animal whole body and human brain scanning. (21st March 2019)
- Record Type:
- Journal Article
- Title:
- Mini EXPLORER II: a prototype high-sensitivity PET/CT scanner for companion animal whole body and human brain scanning. (21st March 2019)
- Main Title:
- Mini EXPLORER II: a prototype high-sensitivity PET/CT scanner for companion animal whole body and human brain scanning
- Authors:
- Lv, Yang
Lv, Xinyu
Liu, Weiping
Judenhofer, Martin S
Zwingenberger, Allison
Wisner, Erik
Berg, Eric
McKenney, Sarah
Leung, Edwin
Spencer, Benjamin A
Cherry, Simon R
Badawi, Ramsey D - Abstract:
- Abstract: As part of the EXPLORER total-body positron emission tomography (PET) project, we have designed and built a high-resolution, high-sensitivity PET/CT scanner, which is expected to have excellent performance for companion animal whole body and human brain imaging. The PET component has a ring diameter of 52 cm and an axial field of view of 48.3 cm. The detector modules are composed of arrays of lutetium (yttrium) oxyorthosilicate (LYSO) crystals of dimensions 2.76 × 2.76 × 18.1 mm 3 coupled to silicon photomultipliers (SiPMs) for read-out. The CT component is a 24 detector row CT scanner with a 50 kW x-ray tube. PET system time-of-flight resolution was measured to be 409 ± 39 ps and average system energy resolution was 11.7% ± 1.5% at 511 keV. The NEMA NU2-2012 system sensitivity was found to be 52–54 kcps MBq −1 . Spatial resolution was 2.6 mm at 10 mm from the center of the FOV and 2.0 mm rods were clearly resolved on a mini-Derenzo phantom. Peak noise-equivalent count (NEC) rate, using the NEMA NU 2-2012 phantom, was measured to be 314 kcps at 9.2 kBq cc −1 . The CT scanner passed the technical components of the American College of Radiology (ACR) accreditation tests. We have also performed scans of a Hoffman brain phantom and we show images from the first canine patient imaged on this device.
- Is Part Of:
- Physics in medicine & biology. Volume 64:Number 7(2019:Apr.)
- Journal:
- Physics in medicine & biology
- Issue:
- Volume 64:Number 7(2019:Apr.)
- Issue Display:
- Volume 64, Issue 7 (2019)
- Year:
- 2019
- Volume:
- 64
- Issue:
- 7
- Issue Sort Value:
- 2019-0064-0007-0000
- Page Start:
- Page End:
- Publication Date:
- 2019-03-21
- Subjects:
- total-body PET -- PET/CT -- companion animal imaging -- EXPLORER -- brain PET
Biophysics -- Periodicals
Medical physics -- Periodicals
610.153 - Journal URLs:
- http://ioppublishing.org/ ↗
http://iopscience.iop.org/0031-9155 ↗ - DOI:
- 10.1088/1361-6560/aafc6c ↗
- Languages:
- English
- ISSNs:
- 0031-9155
- Deposit Type:
- Legaldeposit
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- Available online (eLD content is only available in our Reading Rooms) ↗
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