Assessing Cochlear-Place Specific Temporal Coding Using Multi-Band Complex Tones to Measure Envelope-Following Responses. (21st May 2019)

• Record Type: Journal Article
• Authors: Wang, Le; Bharadwaj, Hari; Shinn-Cunningham, Barbara
• Is Part Of: Neuroscience. Volume 407(2019)
• Page Start: 67
• Page End: 74
• Publication Date: 2019-05-21
• Subjects: cochlear synaptopathy -- hidden hearing loss -- spread of excitation -- coding fidelity; AN auditory nerve -- ASSR auditory steady-state response -- CF center frequency -- cPCA complex principal component analysis -- EEG electroencephalography -- EFR envelope-following response -- IHC inner hair cell -- PCA principal component analysis -- PLV phase-locking value -- PSD power spectral density -- SNR signal-to-noise ratio -- SPL sound pressure level; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2019.02.003
• Languages: English
• ISSNs: 0306-4522

Abstract

Abstract: Previous studies suggest that envelope-following responses (EFRs) reveal important differences in temporal coding fidelity amongst listeners who have normal hearing thresholds, consistent with these listeners differing in the degree to which they suffer from cochlear synaptopathy. Like conventional hearing loss, the severity of cochlear synaptopathy may vary along the cochlea. A number of earlier studies have suggested methods for estimating EFRs driven by specific frequency regions of the cochlea, which would allow synaptopathy to be estimated as a function of cochlear place. Here, we tested a method for measuring EFRs from multiple locations along the cochlea simultaneously, using narrowband stimuli. We compared responses to multiple simultaneous narrowband complex harmonic tones in three non-overlapping frequency bands, each having a unique fundamental frequency, to responses to the individual narrowband stimuli alone, and to responses when noise was added to different combinations of the frequency bands. Our results suggest that simultaneous presentation of multiple tone complexes with different fundamental frequencies leads to repeatable measures of temporal coding fidelity at the cochlear frequency regions corresponding to the narrowband carrier frequencies. Other results suggested that while off-frequency contributions to EFRs driven by narrowband signals (due to spread of excitation) can add destructively to the on frequency response, these interactions were small compared to EFR magnitude. Overall, our results point to the utility of using multi-band complex tone stimuli to estimate the profile of temporal coding fidelity, and thus the degree of synaptopathy, as a function of cochlear place. This article is part of a Special Issue entitled: Hearing Loss, Tinnitus, Hyperacusis, Central Gain. Highlights: Envelope-following responses (EFRs) reflect temporal fidelity in suprathreshold sound coding. Simultaneous narrowband carriers may allow temporal coding assessment at distinct cochlear places. Single-band EFRs and EFRs measured with noise maskers confirm place specificity of multiband EFRs. Off-frequency contributions to narrowband EFRs are modest, but may add destructively to responses. Multiband EFRs may be useful for assessing suprathreshold coding as a function of cochlear place.