Association between Insulin-Like Growth Factor-1 and Uric Acid in Chinese Children and Adolescents with Idiopathic Short Stature: A Cross-Sectional Study. (28th January 2018)

• Record Type: Journal Article
• Authors: Wang, Panpan; Ji, Baolan; Shao, Qian; Zhang, Mei; Ban, Bo
• Other Names: Prodam Flavia Academic Editor.
• Is Part Of: BioMed research international. Volume 2018(2018)
• Publication Date: 2018-01-28
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2018/4259098
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Objective . The aim of this study was to examine the relationship between insulin-like growth factor-1 (IGF-1) and serum uric acid (UA) in Chinese children and adolescents with idiopathic short stature (ISS). Methods . A cross-sectional study of 91 Chinese children and adolescents with ISS was performed. Anthropometric measurements and biochemical parameters were tested. The standard deviation score of IGF-1 (IGF-1 SDS) was calculated. Results . A univariate analysis displayed a significant positive correlation between IGF-1 SDS and UA (P = 0.004 ). In multivariate piecewise linear regression, the levels of IGF-1 SDS increased with the elevation of UA when UA was between 168 μ mol/L and 301 μ mol/L ( β 0.010, 95% CI 0.004–0.017;P = 0.002 ). The levels of IGF-1 SDS decreased with the elevation of UA when UA was either less than 168 μ mol/L ( β −0.055, 95% CI −0.081–−0.028;P < 0.001 ) or more than 301 μ mol/L ( β −0.005, 95% CI −0.013–0.002;P = 0.174 ). Conclusions . This study demonstrated a nonlinear relationship between IGF-1 and UA levels in Chinese children and adolescents with ISS. This finding suggests that either high or low levels of UA may have an adverse effect on IGF-1, whereas appropriate UA levels have a beneficial effect.