Expression and Prognostic Significance of Macrophage Inflammatory Protein-3 Alpha and Cystatin A in Nasopharyngeal Carcinoma. (8th November 2015)

• Record Type: Journal Article
• Authors: Tang, Minzhong; Ou, Ningjiang; Li, Cheng; Lu, Aiying; Li, Jun; Ma, Liping; Zhong, Weiming; Gao, Jianquan; Zheng, Yuming; Cai, Yonglin
• Other Names: Cantile Monica Academic Editor.
• Is Part Of: BioMed research international. Volume 2015(2015)
• Publication Date: 2015-11-08
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2015/617143
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : This study aims to investigate the expression of macrophage inflammatory protein-3 alpha (MIP-3 α ) and cystatin A in nasopharyngeal carcinoma (NPC) and their association with clinical characteristics and prognosis. Primary tumor specimens from 114 NPC patients and associated clinical follow-up data were collected, and the expression of MIP-3 α and cystatin A proteins was investigated by immunohistochemistry. Expression of MIP-3 α was significantly associated with TNM stage in patients with NPC (P < 0.05 ). NPC patients with positive expression of MIP-3 α exhibited shorter median overall survival (OS) and distant metastasis-free survival (DMFS), compared with patients with negative expression (OS: 50.5 months versus 59.0 months, P = 0.013 ; DMFS: 50.1 months versus 60.2 months, P = 0.003 ). NPC patients with positive expression of cystatin A exhibited shorter median OS, local recurrence-free survival (LRFS), and DMFS, compared with patients with negative expression (OS: 51.1 months versus 60.0 months, P = 0.004 ; LRFS: 54.5 months versus 59.5 months, P = 0.036 ; DMFS: 52.3 months versus 58.8 months, P = 0.036 ). Both MIP-3 α and cystatin A overexpressions in NPC tumor tissues were strong independent factors of poor prognosis in NPC patients. MIP-3 α and cystatin A expressions may be valuable prognostic markers in NPC patients.