Degradation and interaction with bone of magnesium alloy WE43 implants: A long-term follow-up in vivo rat tibia study. (April 2019)

• Record Type: Journal Article
• Authors: Oshibe, Narumi; Marukawa, Eriko; Yoda, Tetsuya; Harada, Hiroyuki
• Is Part Of: Journal of biomaterials applications. Volume 33:Number 9(2019)
• Page Start: 1157
• Page End: 1167
• Publication Date: 2019-04
• Subjects: Biodegradable implants -- magnesium alloys -- anodization -- osteosynthesis -- in vivo study; Biomedical engineering -- Periodicals; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1177/0885328218822050
• Languages: English
• ISSNs: 0885-3282

Abstract

The aim of this in vivo study was to examine the degradation and biocompatibility of the WE43 magnesium alloy containing magnesium yttrium, rare earth elements, and zirconium over a one-year long-term follow-up period. Additionally, we compared anodized WE43 implants with monolithic ones and clarified the effect of the anodization. WE43 cylindrical implants with and without anodization (length, 10 mm; diameter, 0.3 mm) were transplanted into the rat tibia. In both groups, the development of corrosion and the change in implant volume were evaluated by in vivo micro-computed tomography until 12 months, and the bone tissue reaction was observed histologically. In the monolithic WE43 implants, hydrogen gas was evident until 14 days and the volume loss was 36.3% after 12 months. In the anodized WE43 implants, the development of hydrogen gas was inhibited and the volume loss was 27.7% after 12 months. The anodized WE43 implants showed a significantly slower corrosion process in the early phase. Therefore, these implants may require a prolonged period to degrade completely and may even resist complete degradation. At one year post surgery, bone maturation progressed and lamellar bone structure developed around the implant in both groups. In conclusion, the WE43 implants showed good long-term stability and biocompatibility in bone tissue.