Leptin receptor gene polymorphisms and morbid obesity in Mexican patients. (December 2016)

• Record Type: Journal Article
• Authors: Rojano-Rodriguez, Martin; Beristain-Hernandez, Jose; Zavaleta-Villa, Beatriz; Maravilla, Pablo; Romero-Valdovinos, Mirza; Olivo-Diaz, Angelica
• Is Part Of: Hereditas. Volume 153:Number 1(2016:Jan.)
• Page Start: 1
• Page End: 5
• Publication Date: 2016-12
• Subjects: Genetic susceptibility -- LEPR -- Morbid obesity -- Single nucleotide polymorphisms; Heredity -- Periodicals; Genetics -- Periodicals; Cytogénétique; Génétique; Hérédité; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 576.5
• DOI: 10.1186/s41065-016-0006-0
• Languages: English
• ISSNs: 0018-0661

Abstract

Abstract Background Human obesity is due to a complex interaction among environmental, behavioral, developmental and genetic factors, including the interaction of leptin (LEP) and leptin receptor (LEPR). SeveralLEPR mutations and polymorphisms have been described in patients with early onset severe obesity and hyperphagic eating behavior; however, some contradictory findings have also been reported. In the present study we explored the association of sixLEPR gene polymorphisms in patients with morbid obesity. Findings Twenty eight patients with morbid obesity and 56 non-obese Mexican Mestizo individuals were included. Typing of rs1137100, rs1137101, rs1805134, Ser492Thr, rs1805094 and rs1805096LEPR polymorphisms was performed by PCR and allele specific hybridization. TheLEPR Ser492Thr polymorphism was monomorphic with the presence of only the Ser492Thr-G allele. Allele C and genotype T/C for rs1805134 polymorphism were associated with susceptibility to morbid obesity (p = 0.02 andp = 0.03, respectively). No association was observed with any haplotype. Linkage disequilibrium (LD) showed that five polymorphisms (rs1137100, rs1137101, rs1805134, rs1805094 and rs1805096) were in absolute (D' = 1) but none in perfect (r2 = 1) LD. Conclusions Our results suggest that rs1805134 polymorphism could be involved in the development of morbid obesity, whilst none of the alleles of theLEPR gene, rs1137100, rs1137101, rs1805094 and rs1805096 were associated as risk factors. However, more studies are necessary to confirm or reject this hypothesis.