A hypercoagulable state leading to venous limb gangrene associated with occult lung adenocarcinoma. Issue 5 (25th March 2019)

• Record Type: Journal Article
• Authors: Waite, Matthew M. A.; Martinelli, Anthony W.; Preston, Stephen D.; Gudgin, Emma; Symington, Emily; Rintoul, Robert C.; Peryt, Adam; Coughlin, Patrick; Hayes, Paul; Gilligan, David; Besser, Martin
• Is Part Of: Clinical case reports. Volume 7:Issue 5(2019)
• Page Start: 888
• Page End: 892
• Publication Date: 2019-03-25
• Subjects: argatroban -- dabigatran -- hematology -- hypercoagulability -- lung adenocarcinoma -- respiratory; Medicine -- Periodicals; 616.09
• DOI: 10.1002/ccr3.2106
• Languages: English
• ISSNs: 2050-0904

Abstract

Key Clinical Message: We report a case of lung adenocarcinoma‐associated hypercoagulability leading to venous limb gangrene, managed successfully with argatroban and then dabigatran. Use of idarucizumab permitted diagnostic investigations, leading to targeted antineoplastic therapy with crizotinib, surgical resection with curative intent, and continued survival over 2 years after the index event. Abstract : We report a case of lung adenocarcinoma‐associated hypercoagulability leading to venous limb gangrene, managed successfully with argatroban and then dabigatran. Use of idarucizumab permitted diagnostic investigations, leading to targeted antineoplastic therapy with crizotinib, surgical resection with curative intent, and continued survival over 2 years after the index event.