Simultaneous T Cell Activation and Macrophage Polarization to Promote Potent Tumor Suppression by Iron Oxide‐Embedded Large‐Pore Mesoporous Organosilica Core–Shell Nanospheres. Issue 9 (6th March 2019)

• Record Type: Journal Article
• Authors: Chen, Lin; Ma, Xiaobo; Dang, Meng; Dong, Heng; Hu, Hongming; Su, Xiaodan; Liu, Wenfei; Wang, Qing; Mou, Yongbin; Teng, Zhaogang
• Is Part Of: Advanced healthcare materials. Volume 8:Issue 9(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-03-06
• Subjects: cancer immunotherapy -- iron oxide -- macrophage polarization -- mesoporous organosilica -- T cell activation; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201900039
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Nanomaterial‐based immunotherapy stimulating T cell activation or tumor‐associated macrophage (TAM) conversion holds great promise for promoting tumor suppression. Herein, a novel nanoplatform, iron oxide‐embedded large‐pore mesoporous organosilica nanospheres (IO‐LPMONs), is prepared for the first time to simultaneously activate cytotoxic T cells and polarize macrophages for potent tumor immunotherapy. The IO‐LPMONs have large mesopores (6.3 nm) and inorganic–organic hybrid shells, which contribute to a high payload (500 µg mg −1 ) of the antigen ovalbumin (OVA). The IO‐LPMONs effectively deliver OVA to dendritic cells (DCs) and activate DCs. Subsequently, high activation of both CD4 + and CD8 + effector antigen‐specific T cells is achieved for powerful antitumor effects. Moreover, the IO‐LPMONs also act as an immune modulator to polarize TAMs from an immunosuppressive M2 to a tumor‐killing M1 phenotype, which induces efficient apoptosis of tumor cells. The combined T cell activation and macrophage polarization strategy based on the IO‐LPMONs elicits remarkable combined antitumor effects in vivo, showing great promise for tumor treatment. Abstract : Iron‐oxide‐embedded large‐pore mesoporous organosilica nanospheres (IO‐LPMONs) are prepared to simultaneously active cytotoxic T cells and tumor‐associated macrophage (TAM) conversion for potent antitumor effects. The core‐shell structured IO‐LPMONs have high surface area, large mesopores, huge pore volume, and inorganic‐organic hybrid shells. The crucial role of the IO‐LPMONs in tumor immunotherapy is further highlighted.