Rotavirus Infection Enhances Levels of Autoantibodies Against Islet Cell Antigens GAD65 and IA-2 in Children with Type 1 Diabetes. (4th March 2019)

• Record Type: Journal Article
• Authors: Ataei-Pirkooh, Angila; Tehrani, Mona; Keyvani, Hossein; Esghaei, Maryam; Tavakoli, Ahmad; Nikmanesh, Bahram; Farahmand, Mohammad; Ghaffari, Hadi; Monavari, Seyed Hamidreza
• Is Part Of: Fetal and pediatric pathology. Volume 38:Number 2(2019)
• Page Start: 103
• Page End: 111
• Publication Date: 2019-03-04
• Subjects: type 1 diabetes -- rotavirus -- T1DM -- children -- autoantibodies; Pathology, Molecular -- Periodicals; Pediatrics -- Periodicals; Molecular biology -- Periodicals; Pediatric pathology -- Periodicals; Fetal Diseases -- pathology -- Periodicals; Infant, Newborn, Diseases -- pathology -- Periodicals; Pediatrics -- Periodicals; 618.92007
• DOI: 10.1080/15513815.2018.1547338
• Languages: English
• ISSNs: 1551-3815

Abstract

Abstract: Background : Some studies implicate rotavirus infection as a trigger for the development of type 1 diabetes mellitus (T1DM) in children, however findings are controversial. Objectives: We investigated the link between rotavirus infection and autoantibodies against islet antigens and T1DM in children. Methods : Serum samples from 80 new-onset diabetic and 80 nondiabetic children were screened for anti-rotavirus IgG, anti-GAD65 and anti-IA-2 autoantibodies using ELISA kits. Results: Positivity percentages of anti-rotavirus IgG detection in diabetic and nondiabetic children were 51.3% and 35.0%, respectively ( p = 0.03). The mean anti-GAD65 and anti-IA-2 antibody titers in anti-rotavirus IgG positive samples were statistically higher than that the anti-rotavirus IgG negative samples. A positive correlation was found between anti-rotavirus IgG and anti-GAD65 antibody levels ( p = 0.004; r = 0.22). Conclusions : Our findings support the hypothesis that rotovirus infection may induce T1DM in children.