Cell Kinetics of Hepatic Metastases as a Prognostic Marker in Patients With Advanced Colorectal Carcinoma. Issue 2 (1990)

• Record Type: Journal Article
• Authors: Silvestrini, Rosella; Costa, Aurora; Gennari, Leandro; Doci, Roberto; Bombardieri, Emilio; Bombelli, Luigia
• Is Part Of: HPB surgery. Volume 2:Issue 2(1990)
• Page Start: 135
• Page End: 144
• Publication Date: 1990
• Subjects: Biliary tract -- Surgery -- Periodicals; Liver -- Surgery -- Periodicals; Pancreas -- Surgery -- Periodicals; 617.55
• DOI: 10.1155/1990/12854
• Languages: English
• ISSNs: 0894-8569

Abstract

Abstract : Cell kinetics was determined, as 3 H-thymidine labeling index (LI), in hepatic lesions from 36 patients with primary colorectal carcinoma; LI values ranged from 0.9% to 23.5% and were normally distributed. Cell kinetics was not related to sex or age of the patient, or to liver function. For clinical studies the median LI value of 10% was used to separate slowly and rapidly proliferating lesions. Univariate analysis showed that patients radically resected and with a low LI tumor have a longer disease-free interval and a better probability of 12-month survival than those non-radically resected and with a high LI tumor. When treatment and cell kinetics were taken into consideration, the probability of 12-month survival was 100% for patients with slowly proliferating and radically resected hepatic metastases. Patients with rapidly proliferating tumors, regardless of type of treatment, had the worst prognosis.