Deranged aortic intima-media thickness, plasma triglycerides and granulopoiesis in Sl/Sld mice. Issue 5 (2004)

• Record Type: Journal Article
• Authors: Dileepan, Kottarappat N.; Johnston, Thomas P.; Li, Yuai; Tawfik, Ossama; Stechschulte, Daniel J.
• Is Part Of: Mediators of inflammation. Volume 13:Issue 5/6(2004)
• Page Start: 335
• Page End: 341
• Publication Date: 2004
• Subjects: High-fat diet -- Stem cell factor deficiency -- Mast cell deficiency -- Intima media thickness -- Hypertriglyceridemia; Inflammation -- Mediators -- Periodicals; Biological response modifiers -- Periodicals; Inflammation (Pathologie) -- Médiateurs; Immunomodulateurs; Biological response modifiers; Inflammation -- Mediators; Immunology; Autacoids; Immunologic Factors; Cell Adhesion Molecules; Cell Communication; Cytokines; Inflammation; Periodicals; Electronic journals; 616.0473
• DOI: 10.1080/09629350400008794
• Languages: English
• ISSNs: 0962-9351

Abstract

Abstract : STUDIES were carried out to evaluate the impact of a high-fat dietary regimen on aortic wall thickness, peripheral blood leukocyte profile, and plasma cholesterol and triglyceride levels in the mast cell-deficient Sl/Sl d mouse. The results demonstrated that the mean aortic wall thickness of Sl/Sl d mice was significantly higher than their normal littermates, and were increased in both genotypes after a 17-day high-fat regimen. In comparison with normal littermates, Sl/Sl d genotypes had elevated levels of plasma triglycerides with normal levels of plasma cholesterol, and the high-fat diet markedly lowered the triglyceride levels. Total peripheral blood leukocytes, the monocyte and granulocyte counts, and hemoglobin levels were significantly lower in Sl/Sl d mice, although the number of lymphocytes, eosinophils and basophils were the same in both genotypes. Interestingly, the high-fat diet regimen elevated leukocyte counts and the number of monocytes and granulocytes in Sl/Sl d mice.