Radiation-Induced Leiomyosarcoma: Does Antimetabolite Chemotherapy Contribute? A Report of Three Cases. (2003)

• Record Type: Journal Article
• Authors: Brockstein, Bruce; Mundt, Arno; Haraf, Daniel J.; Ferguson, Mark; Montag, Anthony
• Is Part Of: Sarcoma. Volume 7:Number 3/4(2003)
• Page Start: 167
• Page End: 172
• Publication Date: 2003
• Subjects: Sarcoma -- Periodicals; 616.994
• DOI: 10.1080/13577140310001650330
• Languages: English
• ISSNs: 1357-714X

Abstract

Abstract : Purpose: Radiation therapy in low and high doses is known to be associated with the occurrence of late secondary sarcomas. The addition of chemotherapy has not been clearly demonstrated as a contributing factor. We describe three patients with radiation-associated leiomyosarcoma who had also received antimetabolite chemotherapy. Methods: Three cases of leiomyosarcoma occurring 9–27 years after radiation and antimetabolite chemotherapy are presented, along with histopathological details. A Medline search was used to assess prior reports of leiomyosarcoma after radiation. Results: These three cases appear to be the first reported in which leiomyosarcoma followed therapy with radiation and antimetabolites. Discussion: With the increasing use of antimetabolite therapy combined with radiation, there is the potential for more occurrences of leiomyosarcoma or other post-treatment sarcomas.