Evaluating drug-drug interaction information in NDF-RT and DrugBank. Issue 1 (December 2015)

• Record Type: Journal Article
• Authors: Peters, Lee; Bahr, Nathan; Bodenreider, Olivier
• Is Part Of: Journal of biomedical semantics. Volume 6:Issue 1(2015)
• Page Start: 1
• Page End: 10
• Publication Date: 2015-12
• Subjects: Drug-drug interactions -- NDF-RT -- DrugBank; Semantics -- Periodicals; Medicine -- Research -- Periodicals; Biology -- Research -- Periodicals; Computer systems -- Periodicals; Bioinformatics -- Periodicals; 570.285
• DOI: 10.1186/s13326-015-0018-0
• Languages: English
• ISSNs: 2041-1480

Abstract

Abstract Background There is limited consensus among drug information sources on what constitutes drug-drug interactions (DDIs). We investigate DDI information in two publicly available sources, NDF-RT and DrugBank. Methods We acquire drug-drug interactions from NDF-RT and DrugBank, and normalize the drugs to RxNorm. We compare interactions between NDF-RT and DrugBank and evaluate both sources against a reference list of 360 critical interactions. We compare the interactions detected with NDF-RT and DrugBank on a large prescription dataset. Finally, we contrast NDF-RT and DrugBank against a commercial source. Results DrugBank drug-drug interaction information has limited overlap with NDF-RT (24-30%). The coverage of the reference set by both sources is about 60%. Applied to a prescription dataset of 35.5M pairs of co-prescribed systemic clinical drugs, NDF-RT would have identified 808, 285 interactions, while DrugBank would have identified 1, 170, 693. Of these, 382, 833 are common. The commercial source Multum provides a more systematic coverage (91%) of the reference list. Conclusions This investigation confirms the limited overlap of DDI information between NDF-RT and DrugBank. Additional research is required to determine which source is better, if any. Usage of any of these sources in clinical decision systems should disclose these limitations.